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This study proposes a Computer-Aided Diagnosis (CAD) system to detect and identify breast lesions from Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI). The presented CAD system consists of four steps: breast segmentation, lesion detection, feature extraction and lesion classification. For breast segmentation, an atlas-based method using FCM is presented to separate the breast region. By using an Otsu threshold, lesions are detected, and False Positives (FPs) resulted by vessels are reduced using Hessian-based filter. Afterwards, efficient features that boost the discriminative power of classification are extracted from the detected lesions. Dual-Tree Complex Wavelet Transform (DT-CWT) has been extracted in a certain decomposition level as a new feature and then has been applied to improve the classification of tumours into classes of malignant and benign. Typically, tumours are in two forms: mass and non-mass. Since non-mass lesions are more challenging to explore, these types are considered more importantly. The Support Vector Machine (SVM) classifier along with different kernels and combination of Linear Discriminant Analysis (LDA) method and k-Nearest Neighbour (k-NN) classifier are used to evaluate the lesion classification process. By applying the DT-CWT to the SVM classifier, the AUC values of 0.71, 0.77 and 0.70 have been achieved for mass-like lesions, non-mass-like lesions and their combination, respectively. By applying the DT-CWT to the k-NN classifier, the AUC values of 0.70, 0.68 and 0.69 have been resulted for mass-like lesions, non-mass-like lesions and their combination, respectively.
Breast DCE-MRI, Atlas-based segmentation, Dual-Tree Complex Wavelet Transform (DT-CWT), SVM classification
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